What happens if you take modafinil with caffeine?

Modafinil (Modalert 200) plus coffee may boost wakefulness and alertness. Some people may experience overstimulation, jitteriness, anxiety, and elevated heart rate with this combination. Caffeine and Modafinil enhance wakefulness differently. Modafinil concentrates on neurotransmitters including dopamine, histamine, and norepinephrine, whereas caffeine inhibits brain adenosine receptors, avoiding tiredness. For lengthy work shifts or sleep loss, Modafinil plus coffee may help. Mixing these drugs might have side effects, so be careful. Start with lesser dosages of Modafinil and coffee and gradually increase as required while watching your reaction. Before beginning a new regimen, ask a doctor about drug and health condition interactions.